OCT4, Ki-67 and VEGF as Prognostic Factors in Endometrial Carcinoma and Their Role in The Differentiation between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinoma: an Immunohistochemical study

Background: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population epithelial stem cells was identified in the human endometrium, these may serve as a source putative carcinoma. The most important member cancer cell markers is OCT-4. Both tumor proliferation (Ki-67) and angiogenesis seem to be for development aggressive tumors. Aim Work: This study aimed evaluate expression OCT4, Ki-67 VEGF hyperplasia differentiate between grade 1 atypical hyperplasia. Materials Methods: 60 cases 60 were stained by Ki-67and immunohistochemical markers. Results: OCT-4 significantly increased with advanced stage (P value = 0.001, 0.044) respectively. There also significant association 0.0016, 0.049) 0.001) both. As regards correlation results versus cases, marker relation. Conclusion: OCT-4, expressions showed positive pathological parameters. labelling index can used differentiation atypia